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KMID : 0043320060290121086
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Archives of Pharmacal Research
2006 Volume.29 No. 12 p.1086 ~ p.1090
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Cytotoxic Phenolic Constituents of Acer tegmentosum Maxim
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Park Ki-Myun
Yang Min-Cheol
Lee Kyu-Ha
Kim Kyung-Ran
Choi Sang-Un
Lee Kang-Ro
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Abstract
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The chromatographic separation of the MeOH extract from the twigs of Acer tegmentosum led to the isolation of ten phenolic compounds. The structures of these compounds were determined using spectroscopic methods as 3,7,3’,4’-tetramethyl-quercetin (1), 5,3’-dihydroxy-3,7,4’-trimethoxy flavone (2), 2,6-dimethoxy-p-hydroquinone (3), (-)-catechin (4), morin-3-O--L-lyxoside (5), p-hydroxy phenylethyl-O--D-glucopyranoside (6), 3,5-dimethoxy-4-hydroxy phenyl-1-O--D-glucoside (7), fraxin (8), 3,5-dimethoxy-benzyl alcohol 4-O--D-glucopyranoside (9) and 4-(2,3-dihydroxy propyl)-2,6-dimethoxy phenyl -D-glucopyranoside (10). The compounds were examined for their cytotoxic activity against five cancer cell lines. Compound 3 exhibited good cytotoxic activity against five human cancer cell lines with values ranging from .
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KEYWORD
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Acer tegmentosum, Acereaceae, Phenolic glycosides, Cytotoxicity
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